Sublingual immunization with recombinant adenovirus encoding SARS-CoV spike protein induces systemic and mucosal immunity without redirection of the virus to the brain.
Identifieur interne : 001C48 ( Main/Exploration ); précédent : 001C47; suivant : 001C49Sublingual immunization with recombinant adenovirus encoding SARS-CoV spike protein induces systemic and mucosal immunity without redirection of the virus to the brain.
Auteurs : Byoung-Shik Shim [Corée du Sud] ; Konrad Stadler ; Huan Huu Nguyen ; Cheol-Heui Yun ; Dong Wook Kim ; Jun Chang ; Cecil Czerkinsky ; Man Ki SongSource :
- Virology journal [ 1743-422X ] ; 2012.
Descripteurs français
- KwdFr :
- Administration par voie sublinguale, Animaux, Anticorps antiviraux (immunologie), Encéphale (immunologie), Encéphale (virologie), Femelle, Glycoprotéine de spicule des coronavirus, Glycoprotéines membranaires (administration et posologie), Glycoprotéines membranaires (génétique), Glycoprotéines membranaires (immunologie), Humains, Immunisation, Immunité muqueuse, Protéines de l'enveloppe virale (administration et posologie), Protéines de l'enveloppe virale (génétique), Protéines de l'enveloppe virale (immunologie), Souris, Souris de lignée BALB C, Syndrome respiratoire aigu sévère (immunologie), Syndrome respiratoire aigu sévère (virologie), Vaccins antiviraux (administration et posologie), Vaccins antiviraux (génétique), Vaccins antiviraux (immunologie), Virus du SRAS (génétique), Virus du SRAS (immunologie).
- MESH :
- administration et posologie : Glycoprotéines membranaires, Protéines de l'enveloppe virale, Vaccins antiviraux.
- génétique : Glycoprotéines membranaires, Protéines de l'enveloppe virale, Vaccins antiviraux, Virus du SRAS.
- immunologie : Anticorps antiviraux, Encéphale, Glycoprotéines membranaires, Protéines de l'enveloppe virale, Syndrome respiratoire aigu sévère, Vaccins antiviraux, Virus du SRAS.
- virologie : Encéphale, Syndrome respiratoire aigu sévère.
- Administration par voie sublinguale, Animaux, Femelle, Glycoprotéine de spicule des coronavirus, Humains, Immunisation, Immunité muqueuse, Souris, Souris de lignée BALB C.
English descriptors
- KwdEn :
- Administration, Sublingual, Animals, Antibodies, Viral (immunology), Brain (immunology), Brain (virology), Female, Humans, Immunity, Mucosal, Immunization, Membrane Glycoproteins (administration & dosage), Membrane Glycoproteins (genetics), Membrane Glycoproteins (immunology), Mice, Mice, Inbred BALB C, SARS Virus (genetics), SARS Virus (immunology), Severe Acute Respiratory Syndrome (immunology), Severe Acute Respiratory Syndrome (virology), Spike Glycoprotein, Coronavirus, Viral Envelope Proteins (administration & dosage), Viral Envelope Proteins (genetics), Viral Envelope Proteins (immunology), Viral Vaccines (administration & dosage), Viral Vaccines (genetics), Viral Vaccines (immunology).
- MESH :
- chemical , administration & dosage : Membrane Glycoproteins, Viral Envelope Proteins, Viral Vaccines.
- chemical , genetics : Membrane Glycoproteins, Viral Envelope Proteins, Viral Vaccines.
- chemical , immunology : Antibodies, Viral, Membrane Glycoproteins, Viral Envelope Proteins, Viral Vaccines.
- genetics : SARS Virus.
- immunology : Brain, SARS Virus, Severe Acute Respiratory Syndrome.
- virology : Brain, Severe Acute Respiratory Syndrome.
- Administration, Sublingual, Animals, Female, Humans, Immunity, Mucosal, Immunization, Mice, Mice, Inbred BALB C, Spike Glycoprotein, Coronavirus.
Abstract
Sublingual (s.l.) administration of soluble protein antigens, inactivated viruses, or virus-like particles has been shown to induce broad immune responses in mucosal and extra-mucosal tissues. Recombinant replication-defective adenovirus vectors (rADVs) infect mucosa surface and therefore can serve as a mucosal antigen delivery vehicle. In this study we examined whether s.l. immunization with rADV encoding spike protein (S) (rADV-S) of severe acute respiratory syndrome-associated coronavirus (SARS-CoV) induces protective immunity against SARS-CoV and could serve as a safe mucosal route for delivery of rADV.
DOI: 10.1186/1743-422X-9-215
PubMed: 22995185
Affiliations:
Links toward previous steps (curation, corpus...)
- to stream PubMed, to step Corpus: 001303
- to stream PubMed, to step Curation: 001303
- to stream PubMed, to step Checkpoint: 001273
- to stream Ncbi, to step Merge: 002565
- to stream Ncbi, to step Curation: 002565
- to stream Ncbi, to step Checkpoint: 002565
- to stream Main, to step Merge: 001C59
- to stream Main, to step Curation: 001C48
Le document en format XML
<record><TEI><teiHeader><fileDesc><titleStmt><title xml:lang="en">Sublingual immunization with recombinant adenovirus encoding SARS-CoV spike protein induces systemic and mucosal immunity without redirection of the virus to the brain.</title><author><name sortKey="Shim, Byoung Shik" sort="Shim, Byoung Shik" uniqKey="Shim B" first="Byoung-Shik" last="Shim">Byoung-Shik Shim</name><affiliation wicri:level="1"><nlm:affiliation>Laboratory Sciences Division, International Vaccine Institute, Seoul, 151-919, Republic of Korea.</nlm:affiliation><country xml:lang="fr">Corée du Sud</country><wicri:regionArea>Laboratory Sciences Division, International Vaccine Institute, Seoul, 151-919</wicri:regionArea><wicri:noRegion>151-919</wicri:noRegion></affiliation></author><author><name sortKey="Stadler, Konrad" sort="Stadler, Konrad" uniqKey="Stadler K" first="Konrad" last="Stadler">Konrad Stadler</name></author><author><name sortKey="Nguyen, Huan Huu" sort="Nguyen, Huan Huu" uniqKey="Nguyen H" first="Huan Huu" last="Nguyen">Huan Huu Nguyen</name></author><author><name sortKey="Yun, Cheol Heui" sort="Yun, Cheol Heui" uniqKey="Yun C" first="Cheol-Heui" last="Yun">Cheol-Heui Yun</name></author><author><name sortKey="Kim, Dong Wook" sort="Kim, Dong Wook" uniqKey="Kim D" first="Dong Wook" last="Kim">Dong Wook Kim</name></author><author><name sortKey="Chang, Jun" sort="Chang, Jun" uniqKey="Chang J" first="Jun" last="Chang">Jun Chang</name></author><author><name sortKey="Czerkinsky, Cecil" sort="Czerkinsky, Cecil" uniqKey="Czerkinsky C" first="Cecil" last="Czerkinsky">Cecil Czerkinsky</name></author><author><name sortKey="Song, Man Ki" sort="Song, Man Ki" uniqKey="Song M" first="Man Ki" last="Song">Man Ki Song</name></author></titleStmt><publicationStmt><idno type="wicri:source">PubMed</idno><date when="2012">2012</date><idno type="RBID">pubmed:22995185</idno><idno type="pmid">22995185</idno><idno type="doi">10.1186/1743-422X-9-215</idno><idno type="wicri:Area/PubMed/Corpus">001303</idno><idno type="wicri:explorRef" wicri:stream="PubMed" wicri:step="Corpus" wicri:corpus="PubMed">001303</idno><idno type="wicri:Area/PubMed/Curation">001303</idno><idno type="wicri:explorRef" wicri:stream="PubMed" wicri:step="Curation">001303</idno><idno type="wicri:Area/PubMed/Checkpoint">001273</idno><idno type="wicri:explorRef" wicri:stream="Checkpoint" wicri:step="PubMed">001273</idno><idno type="wicri:Area/Ncbi/Merge">002565</idno><idno type="wicri:Area/Ncbi/Curation">002565</idno><idno type="wicri:Area/Ncbi/Checkpoint">002565</idno><idno type="wicri:Area/Main/Merge">001C59</idno><idno type="wicri:Area/Main/Curation">001C48</idno><idno type="wicri:Area/Main/Exploration">001C48</idno></publicationStmt><sourceDesc><biblStruct><analytic><title xml:lang="en">Sublingual immunization with recombinant adenovirus encoding SARS-CoV spike protein induces systemic and mucosal immunity without redirection of the virus to the brain.</title><author><name sortKey="Shim, Byoung Shik" sort="Shim, Byoung Shik" uniqKey="Shim B" first="Byoung-Shik" last="Shim">Byoung-Shik Shim</name><affiliation wicri:level="1"><nlm:affiliation>Laboratory Sciences Division, International Vaccine Institute, Seoul, 151-919, Republic of Korea.</nlm:affiliation><country xml:lang="fr">Corée du Sud</country><wicri:regionArea>Laboratory Sciences Division, International Vaccine Institute, Seoul, 151-919</wicri:regionArea><wicri:noRegion>151-919</wicri:noRegion></affiliation></author><author><name sortKey="Stadler, Konrad" sort="Stadler, Konrad" uniqKey="Stadler K" first="Konrad" last="Stadler">Konrad Stadler</name></author><author><name sortKey="Nguyen, Huan Huu" sort="Nguyen, Huan Huu" uniqKey="Nguyen H" first="Huan Huu" last="Nguyen">Huan Huu Nguyen</name></author><author><name sortKey="Yun, Cheol Heui" sort="Yun, Cheol Heui" uniqKey="Yun C" first="Cheol-Heui" last="Yun">Cheol-Heui Yun</name></author><author><name sortKey="Kim, Dong Wook" sort="Kim, Dong Wook" uniqKey="Kim D" first="Dong Wook" last="Kim">Dong Wook Kim</name></author><author><name sortKey="Chang, Jun" sort="Chang, Jun" uniqKey="Chang J" first="Jun" last="Chang">Jun Chang</name></author><author><name sortKey="Czerkinsky, Cecil" sort="Czerkinsky, Cecil" uniqKey="Czerkinsky C" first="Cecil" last="Czerkinsky">Cecil Czerkinsky</name></author><author><name sortKey="Song, Man Ki" sort="Song, Man Ki" uniqKey="Song M" first="Man Ki" last="Song">Man Ki Song</name></author></analytic><series><title level="j">Virology journal</title><idno type="eISSN">1743-422X</idno><imprint><date when="2012" type="published">2012</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Administration, Sublingual</term><term>Animals</term><term>Antibodies, Viral (immunology)</term><term>Brain (immunology)</term><term>Brain (virology)</term><term>Female</term><term>Humans</term><term>Immunity, Mucosal</term><term>Immunization</term><term>Membrane Glycoproteins (administration & dosage)</term><term>Membrane Glycoproteins (genetics)</term><term>Membrane Glycoproteins (immunology)</term><term>Mice</term><term>Mice, Inbred BALB C</term><term>SARS Virus (genetics)</term><term>SARS Virus (immunology)</term><term>Severe Acute Respiratory Syndrome (immunology)</term><term>Severe Acute Respiratory Syndrome (virology)</term><term>Spike Glycoprotein, Coronavirus</term><term>Viral Envelope Proteins (administration & dosage)</term><term>Viral Envelope Proteins (genetics)</term><term>Viral Envelope Proteins (immunology)</term><term>Viral Vaccines (administration & dosage)</term><term>Viral Vaccines (genetics)</term><term>Viral Vaccines (immunology)</term></keywords><keywords scheme="KwdFr" xml:lang="fr"><term>Administration par voie sublinguale</term><term>Animaux</term><term>Anticorps antiviraux (immunologie)</term><term>Encéphale (immunologie)</term><term>Encéphale (virologie)</term><term>Femelle</term><term>Glycoprotéine de spicule des coronavirus</term><term>Glycoprotéines membranaires (administration et posologie)</term><term>Glycoprotéines membranaires (génétique)</term><term>Glycoprotéines membranaires (immunologie)</term><term>Humains</term><term>Immunisation</term><term>Immunité muqueuse</term><term>Protéines de l'enveloppe virale (administration et posologie)</term><term>Protéines de l'enveloppe virale (génétique)</term><term>Protéines de l'enveloppe virale (immunologie)</term><term>Souris</term><term>Souris de lignée BALB C</term><term>Syndrome respiratoire aigu sévère (immunologie)</term><term>Syndrome respiratoire aigu sévère (virologie)</term><term>Vaccins antiviraux (administration et posologie)</term><term>Vaccins antiviraux (génétique)</term><term>Vaccins antiviraux (immunologie)</term><term>Virus du SRAS (génétique)</term><term>Virus du SRAS (immunologie)</term></keywords><keywords scheme="MESH" type="chemical" qualifier="administration & dosage" xml:lang="en"><term>Membrane Glycoproteins</term><term>Viral Envelope Proteins</term><term>Viral Vaccines</term></keywords><keywords scheme="MESH" type="chemical" qualifier="genetics" xml:lang="en"><term>Membrane Glycoproteins</term><term>Viral Envelope Proteins</term><term>Viral Vaccines</term></keywords><keywords scheme="MESH" type="chemical" qualifier="immunology" xml:lang="en"><term>Antibodies, Viral</term><term>Membrane Glycoproteins</term><term>Viral Envelope Proteins</term><term>Viral Vaccines</term></keywords><keywords scheme="MESH" qualifier="administration et posologie" xml:lang="fr"><term>Glycoprotéines membranaires</term><term>Protéines de l'enveloppe virale</term><term>Vaccins antiviraux</term></keywords><keywords scheme="MESH" qualifier="genetics" xml:lang="en"><term>SARS Virus</term></keywords><keywords scheme="MESH" qualifier="génétique" xml:lang="fr"><term>Glycoprotéines membranaires</term><term>Protéines de l'enveloppe virale</term><term>Vaccins antiviraux</term><term>Virus du SRAS</term></keywords><keywords scheme="MESH" qualifier="immunologie" xml:lang="fr"><term>Anticorps antiviraux</term><term>Encéphale</term><term>Glycoprotéines membranaires</term><term>Protéines de l'enveloppe virale</term><term>Syndrome respiratoire aigu sévère</term><term>Vaccins antiviraux</term><term>Virus du SRAS</term></keywords><keywords scheme="MESH" qualifier="immunology" xml:lang="en"><term>Brain</term><term>SARS Virus</term><term>Severe Acute Respiratory Syndrome</term></keywords><keywords scheme="MESH" qualifier="virologie" xml:lang="fr"><term>Encéphale</term><term>Syndrome respiratoire aigu sévère</term></keywords><keywords scheme="MESH" qualifier="virology" xml:lang="en"><term>Brain</term><term>Severe Acute Respiratory Syndrome</term></keywords><keywords scheme="MESH" xml:lang="en"><term>Administration, Sublingual</term><term>Animals</term><term>Female</term><term>Humans</term><term>Immunity, Mucosal</term><term>Immunization</term><term>Mice</term><term>Mice, Inbred BALB C</term><term>Spike Glycoprotein, Coronavirus</term></keywords><keywords scheme="MESH" xml:lang="fr"><term>Administration par voie sublinguale</term><term>Animaux</term><term>Femelle</term><term>Glycoprotéine de spicule des coronavirus</term><term>Humains</term><term>Immunisation</term><term>Immunité muqueuse</term><term>Souris</term><term>Souris de lignée BALB C</term></keywords></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">Sublingual (s.l.) administration of soluble protein antigens, inactivated viruses, or virus-like particles has been shown to induce broad immune responses in mucosal and extra-mucosal tissues. Recombinant replication-defective adenovirus vectors (rADVs) infect mucosa surface and therefore can serve as a mucosal antigen delivery vehicle. In this study we examined whether s.l. immunization with rADV encoding spike protein (S) (rADV-S) of severe acute respiratory syndrome-associated coronavirus (SARS-CoV) induces protective immunity against SARS-CoV and could serve as a safe mucosal route for delivery of rADV.</div></front></TEI><affiliations><list><country><li>Corée du Sud</li></country></list><tree><noCountry><name sortKey="Chang, Jun" sort="Chang, Jun" uniqKey="Chang J" first="Jun" last="Chang">Jun Chang</name><name sortKey="Czerkinsky, Cecil" sort="Czerkinsky, Cecil" uniqKey="Czerkinsky C" first="Cecil" last="Czerkinsky">Cecil Czerkinsky</name><name sortKey="Kim, Dong Wook" sort="Kim, Dong Wook" uniqKey="Kim D" first="Dong Wook" last="Kim">Dong Wook Kim</name><name sortKey="Nguyen, Huan Huu" sort="Nguyen, Huan Huu" uniqKey="Nguyen H" first="Huan Huu" last="Nguyen">Huan Huu Nguyen</name><name sortKey="Song, Man Ki" sort="Song, Man Ki" uniqKey="Song M" first="Man Ki" last="Song">Man Ki Song</name><name sortKey="Stadler, Konrad" sort="Stadler, Konrad" uniqKey="Stadler K" first="Konrad" last="Stadler">Konrad Stadler</name><name sortKey="Yun, Cheol Heui" sort="Yun, Cheol Heui" uniqKey="Yun C" first="Cheol-Heui" last="Yun">Cheol-Heui Yun</name></noCountry><country name="Corée du Sud"><noRegion><name sortKey="Shim, Byoung Shik" sort="Shim, Byoung Shik" uniqKey="Shim B" first="Byoung-Shik" last="Shim">Byoung-Shik Shim</name></noRegion></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
EXPLOR_STEP=$WICRI_ROOT/Sante/explor/SrasV1/Data/Main/Exploration
HfdSelect -h $EXPLOR_STEP/biblio.hfd -nk 001C48 | SxmlIndent | more
Ou
HfdSelect -h $EXPLOR_AREA/Data/Main/Exploration/biblio.hfd -nk 001C48 | SxmlIndent | more
Pour mettre un lien sur cette page dans le réseau Wicri
{{Explor lien
|wiki= Sante
|area= SrasV1
|flux= Main
|étape= Exploration
|type= RBID
|clé= pubmed:22995185
|texte= Sublingual immunization with recombinant adenovirus encoding SARS-CoV spike protein induces systemic and mucosal immunity without redirection of the virus to the brain.
}}
Pour générer des pages wiki
HfdIndexSelect -h $EXPLOR_AREA/Data/Main/Exploration/RBID.i -Sk "pubmed:22995185" \
| HfdSelect -Kh $EXPLOR_AREA/Data/Main/Exploration/biblio.hfd \
| NlmPubMed2Wicri -a SrasV1
| This area was generated with Dilib version V0.6.33. |  |